X-ray induction of methotrexate resistance due todhfr gene amplification

Genomic sequencing.

George M. Church, W Gilbert · Proceedings of the National Academy of Sciences · 1984 · 8.2K citations · Full text

Life Sciences, Genetics, Molecular Biology +12

Separation of Large DNA Molecules by Contour-Clamped Homogeneous Electric Fields

Gilbert Chu, Douglas Vollrath, Ronald W. Davis · Science · 1986 · 1.5K citations

Life Sciences, Biochemistry, Molecular Biology +11

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

Randal J. Kaufman, Peter C. Brown, Robert Schimke · Proceedings of the National Academy of Sciences · 1979 · 398 citations · Full text

Life Sciences, Genetics, Molecular Genetics +11

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

Jack H. Nunberg, Randal J. Kaufman, Robert Schimke et al. · Proceedings of the National Academy of Sciences · 1978 · 394 citations · Full text

Life Sciences, Genetics, Molecular Genetics +12

Double minute chromosomes can be produced from precursors derived from a chromosomal deletion.

S M Carroll, Patrick Gaudray, Charleen M. Moore et al. · Molecular and Cellular Biology · 1988 · 251 citations · Full text

Life Sciences, Genetics, Molecular Biology +12