RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

Florian Otto, Anders Thornell, Tessa Crompton et al. · Cell · 1997 · 2.8K citations · Full text

Developmental Biology, Bone Morphogenic Protein, Genetic Disorder +10

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Leif W. Ellisen, Jeffrey Bird, Daniel C. West et al. · Cell · 1991 · 1.7K citations

Chromatin, Cell Lineage, Developmental Biology +9

Mutations in NOTCH1 cause aortic valve disease

Vidu Garg, Alecia N. Muth, J. Ransom et al. · Nature · 2005 · 1.5K citations

Aortic Diseases, Genetics, Valve Disease +6

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

Qing Wang, Terryl Stacy, Michael Binder et al. · Proceedings of the National Academy of Sciences · 1996 · 1.2K citations · Full text

Genetics, Immunology, Blood Cell +20

Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer

Qing-Lin Li, Kosei Ito, Chohei Sakakura et al. · Cell · 2002 · 1K citations · Full text

Tumor Biology, Oncology, Causal Relationship +10