Concepedia

Assembly of the Isoindolinone Core of Muironolide A by Asymmetric Intramolecular Diels–Alder Cycloaddition

B. S. Flores, Tadeusz F. Molinski

Organic Letters · 2011 · 19 citations · 24 references

DOI

Concepts

Abstract

The hexahydro-1H-isoindolin-1-one core of muironolide A was prepared by asymmetric intramolecular Diels-Alder cycloaddition using a variant of the MacMillan organocatalyst which sets the C4,C5 and C11 stereocenters.

References

24

New Strategies for Organic Catalysis:  The First Highly Enantioselective Organocatalytic Diels−Alder Reaction

Kateri A. Ahrendt, Christopher J. Borths, David W. C. MacMillan · Journal of the American Chemical Society · 2000 · 1.7K citations

, , +9

Horner-wadsworth-emmons reaction: Use of lithium chloride and an amine for base-sensitive compounds

Mary A. Blanchette, William Choy, Jeffery T. Davis et al. · Tetrahedron Letters · 1984 · 910 citations

, , +1

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

Ruo Li Bai, Kenneth D. Paull, Cherry L. Herald et al. · Journal of Biological Chemistry · 1991 · 377 citations · Full text

, , +17

Phorboxazoles A and B: potent cytostatic macrolides from marine sponge Phorbas species

Philip A. Searle, Tadeusz F. Molinski · Journal of the American Chemical Society · 1995 · 287 citations

, , +14

Peloruside A:  A Potent Cytotoxic Macrolide Isolated from the New Zealand Marine Sponge <i>Mycale</i> sp.

Lyndon M. West, Peter T. Northcote, Chris Battershill · The Journal of Organic Chemistry · 1999 · 256 citations

, , +12