Anti hyperglycemic and antihyperlipidemic activity of aerial parts of Aerva lanata Linn Juss in streptozotocin induced diabetic rats

Abstract

To evaluate the effect of methanol extract (MEAL) and aqueous extract (AEAL) of the aerial parts of Aerva lanata Linn Juss (A. lanata) in streptozotocin induced diabetic rat. The streptozotocin induced diabetic rats were orally treated with vehicle (Normal saline), glibenclamide (0.5 mg/kg), MEAL (200 and 400 mg/kg) and AEAL (200 and 400 mg/kg) to the respective treatment groups. The blood glucose level, lipid profile, body weight on 0 day, 1 week and 2 week and biochemical parameters on 2 week of treatment were measured and are compared to the diabetic control rats. MEAL, AEAL and glibenclamide were found to significantly (P<0.01 and P<0.05) reduce the blood glucose level, lipid profile, increase body weight and reduce serum glutamate-oxaloacetate transaminase (SGOT), serum glutamate-pyruvate transaminase (SGPT), creatinine, alkaline phosphatase (ALP), blood urea nitrogen (BUN) and total bilirubin to significant level. The antidiabetic effect was sustained from 1 week onwards till the end of the study. It has been concluded that MEAL and AEAL in addition to the antidiabetic activity, also possess antihyperlipidemic and the normal value of the hepatic biochemical parameters reveals the safety profile of the extract on liver function in the streptozotocin induced diabetic model.