Advanced Synthesis & Catalysis · 2012 · 54 citations · 63 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistrySynthetic Medicinal ChemistryCross-coupling ReactionsHeterocycle SynthesisNatural Product Drug DiscoveryOrganic SynthesisMedicinal Chemistry ApplicationsOxidative CatalysisOxidative Cross-couplingPalladium CatalystsPalladium-catalyzed Cross-couplingPyridine Synthesis
Abstract A novel and efficient protocol for the C‐2 selective olefination of pyridines via a palladium‐catalyzed oxidative cross‐coupling reaction has been developed. A wide range of pyridines and olefin substrates including acrylic ester, styrene, and acrylamide are compatible. The products are highly useful building blocks for the synthesis of bioactive alkaloid natural products and drug molecules.
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