Effects of Recombinant Apolipoprotein A-I _Milano on Aortic Atherosclerosis in Apolipoprotein E–Deficient Mice

Abstract

Recombinant A-I(Milano)/PC prevented progression of aortic atherosclerosis and reduced lipid and macrophage content of plaques in apo E-deficient mice despite severe hypercholesterolemia. Thus, A-I(Milano)/PC may have a role in inhibiting progression and promoting stabilization of atherosclerosis.