Potential marker of oral squamous cell carcinoma aggressiveness detected by fluorescence in situ hybridization in fine‐needle aspiration biopsies

Abstract

The CCND1 numerical aberration is useful both as a prognostic indicator that is independent of the TNM classification, and an indicator to assist in determination of the appropriate treatment for patients with OSCCs. Analysis of the CCND1 numerical aberration using FISH on FNABs may be a useful and practical method for predicting aggressive tumors, recurrence, and clinical outcome in patients with OSCCs.