Anesthesia & Analgesia · 2013 · 20 citations · 12 references
MedicinePharmacologyPharmacotherapyAnesthesiaCritical Care PharmacotherapyRenal PathophysiologyRenal PharmacologyVasopressor TherapyContinuous Infusion PharmacologyDexmedetomidine AnalgesiaDexmedetomidine PharmacologyMechanical Ventilation EffectsSelective Receptor AgonismVasopressin RegulationVasopressin ReleaseVasopressin Secretion
Dexmedetomidine has become a popular sedative in the intensive care unit for patients undergoing mechanical ventilation because of its highly selective α-2 agonism, which exerts a combination of anesthetic, analgesic, and anxiolytic effects. Bradycardia and hypotension have been reported as the most common side effects of its use in large studies. Dexmedetomidine has been reported to induce polyuria by suppressing vasopressin secretion and increasing permeability of the collecting ducts in a dose-dependent fashion. We report a case of dexmedetomidine-related polyuria that occurred with a high-dose continuous infusion and subsequently resolved with discontinuation of the drug. (Anesth Analg 2013;117:150-2).
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