PHENOTYPIC CHARACTERISTICS OF HEREDITARY NON‐POLYPOSIS COLORECTAL CANCER BY THE AMSTERDAM CRITERIA: AN ASIAN PERSPECTIVE

Abstract

This study emphasized the significant left-sided predominance of CRC in Amsterdam I and II-defined patients from our predominantly Chinese population, in contrast to those classically described in Lynch syndrome. Amsterdam criteria thus may not be suitable for diagnosing HNPCC in Asian populations and a greater emphasis should be made towards routine molecular diagnosis of mismatch repair gene defects in suspected HNPCC patients of Asian decent.