Antibiotics A21459 A and B, New Inhibitors of Bacterial Protein Synthesis. I. Taxonomy, Isolation and Characterization.

Abstract

Novel cyclic peptide antibiotics A21459 A and B are produced by a member of the genus Actinoplanes sp. These antibiotics inhibit bacterial protein synthesis and have selective antimicrobial activity against clostridia, mycoplasma and some Gram-negative bacteria.