Diaryl ester prodrugs of fR900098 with improved in vivo antimalarial activity

Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis as Antimalarial Drugs

Hassan Jomaa, Jochen Wiesner, Silke Sanderbrand et al. · Science · 1999 · 1.2K citations

Life Sciences, Biochemistry, Pharmacology +17

A 1-deoxy- <scp>d</scp> -xylulose 5-phosphate reductoisomerase catalyzing the formation of 2- <i>C</i> -methyl- <scp>d</scp> -erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis

Shunji Takahashi, Tomohisa Kuzuyama, Hiroyuki Watanabe et al. · Proceedings of the National Academy of Sciences · 1998 · 466 citations · Full text

Life Sciences, Biochemistry, Microbiology +14

Fosmidomycin, a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis

Tomohisa Kuzuyama, Tomohiro Shimizu, Shunji Takahashi et al. · Tetrahedron Letters · 1998 · 381 citations

Life Sciences, Biochemistry, Molecular Biology +14

Inhibition of the Non-Mevalonate 1-Deoxy-ᴅ-xylulose-5-phosphate Pathway of Plant Isoprenoid Biosynthesis by Fosmidomycin

Johannes Zeidler, Jörg Schwender, Christian Müller et al. · Zeitschrift für Naturforschung C · 1998 · 181 citations · Full text

Life Sciences, Plant Biology, Plant Sciences +10

Synthesis of esters of phosphonoformic acid and their antiherpes activity

Jan Olof Noren, Erik Helgstrand, Nils Gunnar Johansson et al. · Journal of Medicinal Chemistry · 1983 · 60 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +7