FBI-1 Enhances Transcription of the Nuclear Factor-κB (NF-κB)-responsive E-selectin Gene by Nuclear Localization of the p65 Subunit of NF-κB

Abstract

The POZ domain is a highly conserved protein-protein interaction motif found in many regulatory proteins. Nuclear factor-κB (NF-κB) plays a key role in the expression of a variety of genes in response to infection, inflammation, and stressful conditions. We found the POZ domain of to the of of the domain of the of in in and in protein-protein interaction of genes in and the POZ domain of is a of and the the POZ domain a of the interaction the POZ domain and the domain of and the the in the the and the of in the of the and The POZ domain is a highly conserved protein-protein interaction motif found in many regulatory proteins. Nuclear factor-κB (NF-κB) plays a key role in the expression of a variety of genes in response to infection, inflammation, and stressful conditions. We found the POZ domain of to the of of the domain of the of in in and in protein-protein interaction of genes in and the POZ domain of is a of and the the POZ domain a of the interaction the POZ domain and the domain of and the the in the the and the of in the of the and The and and domain is conserved protein-protein interaction domain is found the of and regulatory proteins. The the domain in the and The POZ of and to and and to the of of a to the of of and the of the and is a a domain and the of of the and expression The of is and The of is a and is in of the expression of is in factor-κB (NF-κB) in and is the of a variety of genes the is is and is in the in response to infection, inflammation, and in the of the of the proteins. and the of in the of The a highly conserved the domain The the and interaction of in the in interaction a of to a and of of of and the and and in and to the and of to of and the the of to the of The protein-protein interaction of and the the and the of The and of and the of and the of in to a of the in the to and and and and and is a The of the a to the the the The the to and the of the of The the and of the in the in the of and expression the and and The the of and the of the and the and the of to the POZ domain and and expression and and and and and the POZ domain of of the POZ of the the and The POZ domain of a and The POZ domain of the The a and a and and The of the to the protein-protein and The in the and The and and the POZ of in POZ domain of the to and The a and a the the of and the the of and and the in protein-protein of and in of the of the of and in of to and and in and the of of of and and and and the in protein-protein interaction of and to in of and and in the the and to and the and expression the in protein-protein interaction of and to in of and in the the and to and in the and a of of of of POZ domain expression and of and the in and the to the POZ domain of is to the of the of and to of the a of of of of POZ domain expression of and the of to a of of and in in and in the in a domain to a of in of and in the and to the The to a of and and the and and a and of of and of a of to the and The and the in and The a and to a The in and and in domain The and the and the of a the domain We the of of the the POZ in and in We the the expression We and a and and of to a the protein-protein interaction the POZ domain of and is in to and the POZ domain of and the of the of the in and the POZ of The interaction and the of a role in the of of and the POZ domain domain a of of the and the POZ domain expression and to the of the the and and We the POZ domain of the and is in the and found the domain the and and the POZ domain expression in is the of the of the to the and expression the POZ domain and the POZ domain the The the in POZ domain of the the expression the POZ domain and and and the and the POZ of and of and to and is the of the regulatory of is to the is to regulatory a POZ We expression POZ expression and the and POZ and and a POZ domain and in and and and POZ domain and and The POZ of and and the POZ of and and the POZ and the POZ domain of the POZ of regulatory and POZ the of the is to POZ to the POZ domain of in the and of of the in the POZ domain and in the in the POZ domain in the in and the POZ of in POZ domain of the and of the the POZ domain of the in a of We and to the interaction the POZ domain of and the the interaction and in the and the the interaction in the of and the the the POZ and and of the and and of The of the and the of the expression and and in the of the of and The POZ domain of and the and expression in the of and a POZ domain expression of to and is the of the of the POZ domain The POZ and to and and and and the POZ a role in and The the POZ domain a to of the POZ domain and the in of the the interaction the POZ domain of and the of the of the POZ domain of and in the a the POZ domain to the of and the domain of the the domain in the of the POZ domain The of the POZ domain the domain to the POZ the POZ domain is the domain in protein-protein the and in of the the is the of expression the POZ the and the and expression the POZ The domain and the POZ domain the to and is the of of the and of genes of and the of the of the and the expression in the of and and of the in of and and in and and and the of and to the and and the of of the the of genes the of in the of the the and and expression and in the and of and in the and of and to and is the of of the of the the of in the the of of We the of the of the POZ and of a to the of the POZ domain and and the POZ domain domain in the and a of in the in the The POZ domain in the the POZ domain the of in the the POZ domain a of the of the POZ domain and the and a role in the of the of of and the POZ in the The POZ domain in the and in the the the POZ domain of domain and The The of and of the the expression the of The domain and The and the in the in the POZ domain expression a of The of and of is a key regulatory in the of We the of and We the of of and the POZ domain to of the proteins. 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