Obesity in Albino Mice Due to Single Injections of Goldthioglucose

Abstract

Marked weight gains were produced in stock albino mice by single injections of goldthioglucose. Analysis of total body lipids, protein, water, and ash showed these weight gains to be primarily due to an increase in adipose tissue. This obesity occurred in approximately one-third of the survivors of sublethal doses of goldthioglucose. Except for centrolubular fatty infiltration of the liver in obese animals, no-anatomic lesions were found in the organs examined.