Cx3Cr1 and Vascular Adhesion Protein-1-Dependent Recruitment of Cd16+ Monocytes Across Human Liver Sinusoidal Endothelium

Abstract

Our data suggest that CD16(+) monocytes are recruited by a combination of adhesive signals involving VAP-1 and CX(3)CR1 mediated integrin-activation. Thus a novel combination of surface molecules, including VAP-1 and CX(3)CL1 promotes the recruitment of CD16(+) monocytes to the liver, allowing them to localize at sites of chronic inflammation and fibrosis.