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The Effect of Leukocytic Endogenous Mediator (LEM) on the Tissue Distribution of Zinc and Iron
136
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1972
Year
Iron MetabolismImmunologyLeukocytic Endogenous MediatorTrace Mineral NutritionRedox BiologyOxidative StressInflammationHematologySummaryleukocytic Endogenous MediatorRapid RedistributionToxicologyBiological Inorganic ChemistryHealth SciencesBiochemistryLiver PhysiologyTissue DistributionTrace MetalCell BiologyBioactive MetalMetalloproteinPhysiologyWound HealingMetabolismMedicineHepcidinExtracellular Matrix
SummaryLeukocytic endogenous mediator (LEM) was shown to induce significant alterations in zinc and iron metabolism. Isotopic studies, employing 65Zn and 59Fe demonstrated that LEM stimulated a rapid redistribution of zinc and iron within the tissues of the host, with a significant uptake of these two metals by the liver.