Experimental Biology and Medicine · 1972 · 136 citations · 0 references
MedicineBiochemistryPhysiologyCellular MetabolismMetabolismMineral MetabolismHeavy Metal BioaccumulationHeavy Metal MetabolismIron HomeostasisIron MetabolismIron TransportZinc MetabolismHepatic Iron AccumulationHepatic Metal MetabolismHepatic Zinc MetabolismIron Metabolism RegulationIsotopic Tracer StudiesZinc BiochemistryZinc DistributionZinc Metabolic Regulation
Leukocytic endogenous mediator (LEM) was shown to induce significant alterations in zinc and iron metabolism. Isotopic studies, employing 65Zn and 59Fe demonstrated that LEM stimulated a rapid redistribution of zinc and iron within the tissues of the host, with a significant uptake of these two metals by the liver.