Advantage of High‐surface‐area Charcoal for Gastrointestinal Decontamination in a Human Acetaminophen Ingestion Model

Abstract

The surface area of oral activated charcoal is a major determining factor in its ability to limit acetaminophen absorption and to fulfill its adsorptive role in GI decontamination. In a human acetaminophen overdose model, 2 types of HSA charcoal, when compared with equal doses of LSA charcoal, significantly reduced serum levels and total acetaminophen absorption as measured by the AUC.