p53-PGC-1α Pathway Mediates Oxidative Mitochondrial Damage and Cardiomyocyte Necrosis Induced by Monoamine Oxidase-A Upregulation: Role in Chronic Left Ventricular Dysfunction in Mice - Concepedia

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p53-PGC-1α Pathway Mediates Oxidative Mitochondrial Damage and Cardiomyocyte Necrosis Induced by Monoamine Oxidase-A Upregulation: Role in Chronic Left Ventricular Dysfunction in Mice

DOI Full Paper Access

130

Citations

35

References

2012

Year

Christelle Villeneuve, Céline Guilbeau‐Frugier, Pierre Sicard, Olivier Lairez, Catherine Ordener, Thibaut Duparc, Damien De Paulis, Bettina Couderc, Odile Spreux‐Varoquaux, Florence Tortosa,

Antioxidants and Redox Signaling

Abstract

We provide the first evidence that MAO-A upregulation in the heart causes oxidative mitochondrial damage, p53-dependent repression of PGC-1α, cardiomyocyte necrosis, and chronic ventricular dysfunction.

References

	Year	Citations

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