New Antibacterial Steroidal Alkaloids from<i>Sarcococca Brevifolia</i>

Abstract

Abstract Three new steroidal alkaloids, epipachysamine-E-5-ene-4-one (1), N b-demethylepipachysamine-E-5-ene-4-one (2) and iso-N-formylchonemorphine (3) have been isolated from Sarcococca brevifolia. Structures of these compounds were determined by spectroscopic studies. Compounds 1 and 3 exhibited strong antibacterial activity against Bacillus cereus, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis, Corynebacterium diphtheriae and Pseudomonas aeruginosa.