Respiration · 2009 · 18 citations · 0 references
Veterinary MedicineClinical SciencesToxicologyHypersensitivityPulmonary Function TestingPulmonologyEdemaInhalation TherapyInterstitial Lung DiseaseNitrogen OxidesPulmonary ToxicityRespiratory DiseaseGas Exchange AbnormalitiesLung Function TestingNitrogen Dioxide ToxicityNitrogen Oxide Health EffectsNitrogen Oxide ToxicityNonspecific Interstitial PneumoniaRespiratory Gas ExchangeSteroid Therapy Management
The effects of oxides of nitrogen inhalation are reported in a 21-year-old gardener exposed to silage gas. Initial nausea, cough and fever remitted, but respiratory failure developed 3 weeks later. Roentgenograms and lung function studies revealed pulmonary edema, volume restriction, and severely impaired gas exchange. Needle biopsy showed a nonspecific interstitial pneumonia. With steroid therapy all functional parameters except diffusing capacity returned to normal. Failure to inquire about non-occupational activities led to delayed diagnosis. A brief review of toxic effects of nitrogen oxides is presented.