Signal Hyperintensities on Brain Magnetic Resonance Imaging in Patients with Primary Sjögren Syndrome and Frequent Episodic Tension-type Headache: Relation to Platelet Serotonin Level and Disease Activity

Abstract

Our study showed that SH on brain MRI are more common in specific regions of the brain in pSS patients with FETH than in controls with FETH, signifying a more widespread cerebral vasculopathy in SS patients with FETH. Periventricular SH seem to be associated to increased platelet serotonin release in pSS patients with FETH and correlated with disease duration, without correlation to the actual ESSDAI and markers of immunoinflammation, and might be linked with chronic immunoinflammation of low-grade intensity and vasculitis in pSS.