FACTOR V R506Q MUTATION (ACTIVATED PROTEIN C RESISTANCE) IS AN ADDITIONAL RISK FACTOR FOR EARLY RENAL GRAFT LOSS ASSOCIATED WITH ACUTE VASCULAR REJECTION

Abstract

Renal transplant recipients who are carriers of the FV:Q506 allele have an increased risk of early graft loss. Vascular rejection changes including endothelialitis and fibrinoid vascular necrosis were more common in this group, and therefore an association between the hypercoagulable state, which entails an up-regulation of the mitogenic and proinflammatory enzyme thrombin, and the immunological challenge to the endothelium may be the cause of inferior prognosis in these patients.