Recombinant Ecto-5′-Nucleotidase (CD73) Has Long Lasting Antinociceptive Effects That are Dependent on Adenosine A₁Receptor Activation

Abstract

Our data indicate that the long lasting antinociceptive effects of mNT5E are due to hydrolysis of AMP followed by activation of A1R. Moreover, our data suggest recombinant NT5E could be used to treat chronic pain and to study many other physiological processes that are regulated by NT5E.