Prognostic Value of Positron Emission Tomography with [18F]Fluoro-2-deoxy-D-glucose in the Low-grade Glioma

Abstract

The presence of areas of increased FDG uptake in a histologically proven LGG predicts, in most cases, a deleterious evolution. This metabolic feature, detectable with a noninvasive procedure, may provide a clue to cellular changes, announcing malignant transformation in a tumor that retains the histological features of an LGG. Protocols with aggressive therapeutic strategies in this situation should be considered for evaluation.