Enhanced Activation of Cyclooxygenase‐2 Downregulates Th1 Signaling Pathway in <i>Helicobacter pylori</i>‐infected Human Gastric Mucosa

Abstract

This study provides a mechanism by which H. pylori may actually interfere with normal T-cell activation in human gastric mucosa, possibly enhancing its pathogenicity. The use of COX-2 selective inhibitors as immunomodulators in the course of H. pylori infection deserves investigations.