Pharmacokinetic profile and tolerability of pimobendan in patients with terminal renal insufficiency

Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations

Kiyoshi Yamaoka, Terumichi Nakagawa, Toyozo Uno · Journal of Pharmacokinetics and Biopharmaceutics · 1978 · 2.1K citations

Pharmacy, Clinical Pharmacokinetics, Pharmacokinetics +11

Fully automated high-performance liquid chromatography

Willy Roth, K Beschke, R Jauch et al. · Journal of Chromatography B Biomedical Sciences and Applications · 1981 · 199 citations

Pharmacy, Chemistry, Analytical Chemistry +11

Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties

Pieter D. Verdouw, J. M. Hartog, Dirk J. Duncker et al. · European Journal of Pharmacology · 1986 · 83 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Effect on contractility of skinned fibres from mammalian heart and smooth muscle by a new benzimidazole derivative, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methy l-3(2H )- pyridazinone.

Rüegg Jc, Gabriele Pfitzer, D Eubler et al. · PubMed · 1984 · 57 citations

Natural Sciences, Biophysics, Pharmacology +17

Effects of the benzimidazole derivatives pimobendan and 2-(4-hydroxy-phenyl)-5-(5-methyl-3-oxo-4,5-dihydro-2H-6- pyridazinyl) benzimidazole . HCl on phosphodiesterase activity and force of contraction in guinea-pig hearts.

Christian Berger, Wieland Meyer, Hasso Scholz et al. · PubMed · 1985 · 36 citations

Medicine, Biochemistry, Pharmacology +14