Spontaneous resolution of an axially dissymmetric 3-carbamoylpyridinium iodide; intrinsic discrimination between the enantiomeric forms by the introduction of a second chiral element

Abstract

The direction of the carbonyl-orientation in a solid amide-rotamer of 3-[N-methyl-N-(R)-α-methylbenzyl]carbamoly-1,2,4-trimethylpyridinium iodide is governed by the (R)-chirality in the amide side chain; structures, as determined by X-ray analysis and c.d. spectra, are correlated.