Dissecting the puzzle of life: modularization of signal transduction networks

From molecular to modular cell biology

Leland H. Hartwell, J. J. Hopfield, Stanislas Leibler et al. · Nature · 1999 · 3.6K citations · Full text

Cell Division, Cell Organelle, Multicellular System +5

Emergent Properties of Networks of Biological Signaling Pathways

Upinder S. Bhalla, Ravi Iyengar · Science · 1999 · 1.7K citations · Full text

An amplified sensitivity arising from covalent modification in biological systems.

Albert Goldbeter, Daniel E. Koshland · Proceedings of the National Academy of Sciences · 1981 · 1.2K citations

Modified Protein, Biochemistry, Natural Sciences +14

Ultrasensitivity in the mitogen-activated protein kinase cascade.

Chi‐Ying F. Huang, James E. Ferrell · Proceedings of the National Academy of Sciences · 1996 · 1.2K citations · Full text

Molecular Biology, Oocyte Maturation, Cytoskeleton +18

Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors

Birgit Schoeberl, Claudia Eichler-Jonsson, Ernst Dieter Gilles et al. · Nature Biotechnology · 2002 · 963 citations

Biophysical Modeling, Engineering, Map Kinase Cascade +17