Three New Indole Alkaloids from the Leaves of <i>Kopsia officinalis</i>

Abstract

Abstract Three new indole alkaloids, 11,12‐de(methylenedioxy)danuphylline ( 1 ), methyl (2 β ,11 β ,12 β ,19 α )‐6,7‐didehydro‐8,21‐dioxo‐11,21‐cycloaspidospermidine‐2‐carboxylate ( 2 ), and (2 β ,5 β )‐aspidofractinin‐16‐ol ( 3 ) were isolated from Kopsia officinalis , together with 16 known compounds. Their structures were determined by spectroscopic methods. The isolated known compound (−)‐12‐methoxykopsinaline displayed antimanic effects in Drosophila, with an IC 50 value of 12.5 μg/ml.