Depletion of Passenger Leukocytes from Corneal Grafts: An Effective Means of Promoting Transplant Survival?

Abstract

Anti-CD45 antibody plus complement-mediated targeting of donor tissue is the most efficient way to deplete corneal passenger leukocytes and can considerably reduce the time required for cell depletion. However, depletion of graft passenger leukocytes does not have a significant effect on promoting graft survival even in the HR setting.