Laboratory and Clinical Studies of Gentamicin

Abstract

Article1 November 1963Laboratory and Clinical Studies of GentamicinA New Broad-spectrum AntibioticROGER J. BULGER, M.D., SHELDON SIDELL, M.D., WILLIAM M. M. KIRBY, M.D.ROGER J. BULGER, M.D., SHELDON SIDELL, M.D., WILLIAM M. M. KIRBY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-5-593 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGentamicin*is a new broad-spectrum antibiotic that offers promise in the treatment of infections caused by a wide variety of gram-negative rods. It is an antibiotic mixture of two isomers that share the same antibacterial and pharmacologic principles (1) and that has been isolated by Weinstein and coworkers (2) from two previously undescribed microorganisms of the genus Micromonospora. These two species are calledMicromonospora pupurea n. sp. andMicromonospora echinospora n. sp. Gentamicin has been extensively investigated in our laboratory and in a number of patients, several of whom received careful pharmacologic studies at the Clinical Research Center of the...References1. BLACK J: Personal communication. Google Scholar2. WEINSTEINLUEDEMANNODANWAGMANROSSELETMARQUEZCONIGLIOCHERNEYHERZOGBLACK MJGMEMSHJPJACTWHLJ: Gentamicin, a new antibiotic from micromonospora. Journal of Medicinal Chem. 6: 463, 1963. CrossrefMedlineGoogle Scholar3. KIRBYROSENFELDBRODIE WMLSJ: Oxacillin: laboratory and clinical evaluation. JAMA 181: 739, 1962. CrossrefMedlineGoogle Scholar4. JACKSON GG: Personal communication. Google Scholar5. LOURIA D: Personal communication. Google Scholar6. FINLANDJONESBARNES MWFMW: Occurrence of serious bacterial infections since introduction of antibacterial agents. JAMA 170: 2188, 1959. CrossrefMedlineGoogle Scholar7. MCCABEJACKSON WRGG: Gram-negative bacteremia. Arch. Intern. Med. 110: 847, 1962. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, WashingtonFrom the Department of Medicine, University of Washington School of Medicine and the University Hospital, Seattle, Washington.Drs. Bulger and Sidell are trainees of the United States Public Health Service, and part of the work was supported by training grants 2E-146 and 06-13, The Clinical Research Center, United States Public Health Service, Bethesda, Maryland.Requests for reprints should be addressed to William M. M. Kirby, M.D., Department of Medicine, School of Medicine of the University of Washington, Seattle, Washington.*Developed by Shering Corporation. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAminoglycoside dosing in patients by kidney function and area under the curve: the Sawchuk-Zaske dosing method revisited in the era of obesityWhere it all began! With Sisir K Bose!! 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STEINHAUER, M.D., MAXWELL FINLAND, M.D., F.A.C.P.Über neue ArzneimittelPseudomonas Infections of the Rabbit Cornea* 1 November 1963Volume 59, Issue 5_Part_1Page: 593-604KeywordsAntibioticsAttentionEscherichia coliHospital medicineMedical servicesProteinuriaPseudomonasResearch laboratoriesUreaUrinary tract infections Issue Published: 1 November 1963 CopyrightCopyright ©, 1963, by The American College of PhysiciansPDF DownloadLoading ...