American Burn Association Consensus Conference to Define Sepsis and Infection in Burns

TLDR

Burn patients are chronically exposed to inflammatory mediators and already exhibit systemic inflammatory response syndrome, so conventional sepsis criteria such as fever, tachycardia, tachypnea, and leukocytosis are routinely present and thus less applicable to the burn population. The consensus conference aimed to develop and publish standardized definitions for sepsis and infection-related diagnoses specific to burn patients. ABA experts reviewed the literature and convened on January 20, 2007 in Tucson, Arizona, to formulate consensus definitions, after which a summary of the proceedings was prepared. Adopting these standardized definitions is expected to enhance the conduct of more meaningful multicenter trials across burn centers.

Abstract

Because of their extensive wounds, burn patients are chronically exposed to inflammatory mediators. Thus, burn patients, by definition, already have “systemic inflammatory response syndrome.” Current definitions for sepsis and infection have many criteria (fever, tachycardia, tachypnea, leukocytosis) that are routinely found in patients with extensive burns, making these current definitions less applicable to the burn population. Experts in burn care and research, all members of the American Burn Association, were asked to review the literature and prepare a potential definition on one topic related to sepsis or infection in burn patients. On January 20, 2007, the participants met in Tucson, Arizona to develop consensus for these definitions. After review of the definitions, a summary of the proceedings was prepared. The goal of the consensus conference was to develop and publish standardized definitions for sepsis and infection-related diagnoses in the burn population. Standardized definitions will improve the capability of performing more meaningful multicenter trials among burn centers.