Concepedia

Publication | Open Access

Patients with Malignant Hyperthermia Demonstrate an Altered Calcium Control Mechanism in B Lymphocytes

DOIFull Paper Access

49

Citations

0

References

2002

Year

Yoshitatsu Sei, Barbara W. Brandom, Saiid Bina, Eiji Hosoi, Kathleen L. Gallagher, Hadley Wyre, Paul A. Pudimat, Steve J. Holman, David Venzon, John W. Daly,
Anesthesiology

Abstract

The Ca2+ responses to caffeine or 4-chloro-m-cresol in B lymphocytes showed significant differences between MHS and MHN (or control) individuals. Although the molecular mechanisms of these alterations are currently undetermined, the results suggest that the enhanced Ca2+ responses are associated with mutations in the RYR1 gene in some MHS individuals.