Frequency of Regulatory T Cells is Not Affected by Transient B CellDepletion Using Anti-CD20 Antibodies in Rheumatoid Arthritis

Abstract

Absolute T cell counts showed no significant changes after rituximab compared to the time point before therapy.In particular, the frequency of regulatory T cells with a CD4+CD25++ phenotype as well as positive Foxp3 expression were numerically stable. Additionally, HLA-G positive regulatory T cells and soluble levels of HLA-G showed no significant changes.