Epidermal Growth Factor Promotes Invasiveness of Pancreatic Cancer Cells Through NF-κB-Mediated Proteinase Productions

Abstract

Our findings indicated that NF-kappaB-mediated MMP-9 and uPA induction was responsible for EGF-induced invasiveness in these pancreatic cancer cell lines and implicate that such anti-NF-kappaB therapy as the use of NF-kappaB inhibitors may contribute to the reduction of invasiveness of pancreatic cancer.