Control of Quorum Sensing by a <i>Burkholderia pseudomallei</i> Multidrug Efflux Pump

Abstract

ABSTRACT The Burkholderia pseudomallei KHW quorum-sensing systems produced N -octanoyl-homoserine lactone, N -decanoyl-homoserine lactone, N -(3-hydroxy)-octanoyl-homoserine lactone, N -(3-hydroxy)-decanoyl-homoserine lactone, N -(3-oxo)-decanoyl-homoserine lactone, and N -(3-oxo)-tetradecanoyl-homoserine lactone. The extracellular secretion of these acyl-homoserine lactones is dependent absolutely on the function of the B. pseudomallei BpeAB-OprB efflux pump.