Hypoxia Stimulates Inflammatory and Fibrotic Responses From Nasal‐Polyp Derived Fibroblasts

Abstract

Hypoxic conditions present in the sinus tissue could increase production of proinflammatory and remodeling cytokines that contribute to the inflammation observed in sinusitis. Surgical intervention may help decrease inflammation by allowing reoxygenation of the sinus cavity and decrease the hypoxic induction of cytokines and remodeling factors.