Long‐term bio‐degradation of cross‐linked and non‐cross‐linked collagen barriers in human guided bone regeneration

Abstract

CLMs were more resistant to tissue degradation than NCLMs, and maintained integrity during the study. Neither membrane was resistant to degradation when exposed to the oral environment. CLMs were associated with a higher incidence of tissue perforations. In non-perforated sites, CLM ossification at or within the membrane was occasionally observed.