Topical Diltiazem Cream Versus Botulinum Toxin A for the Treatment of Chronic Anal Fissure

Abstract

BTA yields higher healing rates in the short term, though after 3 months diltiazem and BTA resulted in equal healing rates. Also no significant difference in pain reduction was observed for both treatments. This study shows no significant advantage of one treatment compared to the other. This randomized clinical trial is registered by the Dutch Trial Register as NTR1012.