Direct Arylation of Primary and Secondary sp³ C–H Bonds with Diarylhyperiodonium Salts via Pd Catalysis

Abstract

Palladium-catalyzed primary and secondary sp(3) C-H bond arylation is reported. The method using diarylhyperiodonium salts as arylation reagents shows good functional group tolerance and proceeds under mild reaction conditions. The KIE experiments show that the C-H bond activation is the rate-determining step.