Blood Transfusion

TLDR

The study aimed to determine whether blood transfusion is a consistent, independent risk factor for post‑injury multiple organ failure (MOF) beyond other shock indices. In a 55‑month prospective cohort of 513 trauma patients, the authors performed multiple logistic regression on five data sets that incorporated admission variables, transfusion volume, and sequential shock indices to predict early and late MOF. They identified a dose‑response relationship and found that transfusion remained an independent risk factor in 13 of 15 models, with high odds ratios, confirming it as an early consistent predictor of post‑injury MOF.

Abstract

To determine if blood transfusion is a consistent risk factor for postinjury multiple organ failure (MOF), independent of other shock indexes.A 55-month inception cohort study ending on August 30, 1995. Data characterizing postinjury MOF were prospectively collected. Multiple logistic regression analysis was performed on 5 sets of data. Set 1 included admission data (age, sex, comorbidity, injury mechanism, Glasgow Coma Scale, Injury Severity Score, and systolic blood pressure determined in the emergency department) plus the amount of blood transfused within the first 12 hours. In the subsequent 4 data sets, other indexes of shock (early base deficit, early lactate level, late base deficit, and late lactate level) were sequentially added. Additionally, the same multiple logistic regression analyses were performed with early MOF and late MOF as the outcome variables.Denver General Hospital, Denver, Colo, is a regional level I trauma center.Five hundred thirteen consecutive trauma patients admitted to the trauma intensive care unit with an Injury Severity Score greater than 15 who were older than 16 years and who survived longer than 48 hours.None.The relationship of blood transfusions and other shock indexes with the outcome variable, MOF.A dose-response relationship between early blood transfusion and the later development of MOF was identified. Despite the inclusion of other indexes of shock, blood transfusion was identified as an independent risk factor in 13 of the 15 multiple logistic regression models tested; the odds ratios were high, especially in the early MOF models.Blood transfusion is an early consistent risk factor for postinjury MOF, independent of other indexes of shock.