Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: In vitro and in vivo comparison and calculation of in vivo inhibition constants* - Concepedia

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Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: In vitro and in vivo comparison and calculation of in vivo inhibition constants*

105

Citations

48

References

1997

Year

Agnès Tran, Elisabeth Rey, Gérard Pons, Marina Rousseau, Philippe d’Athis, Georges Olive, Gary Mather, Frances E. Bishop, Colleen J. Wurden, Rita Labroo,

Clinical Pharmacology & Therapeutics

Abstract

Stiripentol appears to inhibit several CYP450 enzymes in vitro and in vivo. In vivo inhibition constants show that stiripentol inhibition of CYP3A4 is linearly related to plasma concentration in patients with epilepsy.

References

	Year	Citations

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