Amyloidosis as the Sole Manifestation of Familial Mediterranean Fever (FMF)

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Article1 November 1962Amyloidosis as the Sole Manifestation of Familial Mediterranean Fever (FMF)Further Evidence of Its Genetic NatureALIZA BLUM, M.D., JOSEPH GAFNI, M.D., EZRA SOHAR, M.D., SHLOMO SHIBOLET, M.D., HARRY HELLER, M.D.ALIZA BLUM, M.D.Search for more papers by this author, JOSEPH GAFNI, M.D.Search for more papers by this author, EZRA SOHAR, M.D.Search for more papers by this author, SHLOMO SHIBOLET, M.D.Search for more papers by this author, HARRY HELLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-5-795 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen amyloidosis was observed in familial Mediterranean fever (1), it seemed obvious to regard it as another example of "secondary" amyloidosis. On closer examination, however, doubts arose. There is, to be sure, the clinical association with attacks of familial Mediterranean fever, but on autopsy, only amyloidosis was found (2-6). A pathologist, lacking clinical information, would classify such a case as "primary," not "secondary," amyloidosis. This alone would be a unique feature, and ought to place the amyloidosis of familial Mediterranean fever in a special category.The appearance of amyloidosis in familial Mediterranean fever is strangely independent of the clinical attacks...References1. HELLERKARIVSHERFSOHAR HJLE: Familial Mediterranean fever. Harefuah 48: 91, 1955. MedlineGoogle Scholar2. HELLERSOHARSHERF HEL: Familial Mediterranean fever. Arch. Intern. Med. 102: 50, 1958. CrossrefGoogle Scholar3. HELLERSOHARGAFNIHELLER HEJJ: Amyloidosis in familial Mediterranean fever, an independent genetically determined character. Arch. Intern. Med. 107: 539, 1961. CrossrefMedlineGoogle Scholar4. TUQAN NA: Periodic disease: a clinical-pathological study. Ann. Intern. Med. 49: 885, 1958. LinkGoogle Scholar5. MILLIEZLAROCHESAMARCOLAGRUE PCPG: Syndrome néphrotique amyloid et maladie périodique. Sem. Hôp. Paris. 37: 775, 1961. Google Scholar6. MAMOU H: La Maladie Périodique, Expansion Scientifique Française, Paris, 1956, p. 169. Google Scholar7. SOHARHELLERPRASHELLER EJMH: Genetics of familial Mediterranean fever, a disorder with recessive inheritance. Arch. Intern. Med. 107: 529, 1961. CrossrefGoogle Scholar8. MISSMAHL H: Welche Beziehung Bestehen zwischen den verschiedenen Formen der Amyloidose und den Bindegewebsfasern? Verh. Deutsch. Ges. Inn. Med. 65: 439, 1959. MedlineGoogle Scholar9. MISSMAHLGAFNI HJ: Peri-reticular and peri-collagen amyloid deposition. The basic lesions of amyloidosis. To be published. Google Scholar10. MISSMAHLGAFNISOHAR HJE: Pericollagen amyloid deposition. The basis of "atypical" distribution in various entities of amyloidosis. To be published. Google Scholar11. GAFNIMISSMAHLSOHARHELLER JHEH: The histological pattern of the amyloidosis of familial Mediterranean fever (FMF). To be published. Google Scholar12. GAFNIMISSMAHLHELLER JHH: The histological pattern of "secondary" amyloidosis. To be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Tel-Aviv,From the Department of Medicine, Tel-Hashomer Hospital, Tel-Aviv, Israel.This study was supported in part by research grant A-2857 of the United States Public Health Service, National Institutes of Health, Bethesda, Maryland.Requests for reprints should be addressed to Harry Heller, M.D., Department of Medicine, Tel-Hashomer Hospital, Tel-Aviv, Israel. 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ILHAN ÖZDEMIR, M.D.Familial Mediterranean feverThe Hereditary Renal DiseasesDeafness, urticaria and amyloidosisPrimary amyloidosisPeriodic DiseaseThe arthritis of familial mediterranean fever (FMF)Grundzüge einer historischen und geographischen PathologiePlasma proteins in familial mediterranean feverAmyloidosis: Its differentiation into perireticulin and peri-collagen typesFamilial paroxysmal polyserositisTHE INHERITED AMYLOIDOSES THEIR CLINICAL AND THEORETICAL SIGNIFICANCEMedical genetics 1962 1 November 1962Volume 57, Issue 5Page: 795-799KeywordsAmyloidosisAutopsyBiopsyFeversGeneticsHospital medicineKidneysMedical servicesPathologistsResearch grants Issue Published: 1 November 1962 PDF downloadLoading ...