Induced Circular Dichroism and UV−Vis Absorption Spectroscopy of Cyclodextrin Inclusion Complexes: Structural Elucidation of Supramolecular Azi-adamantane (Spiro[adamantane-2,3‘-diazirine])

Abstract

The first induced circular dichroism (ICD) analyses of diazirine@cyclodextrin inclusion complexes are reported. The stoichiometries and association constants of the guest@host complexes with α-, β-, and γ-cyclodextrin were determined. In addition, with the α-cyclodextrin complex, UV−vis spectroscopy of water−ethanol solutions showed remarkable fine structure, probably indicating that the diazirine experiences a nonpolar microenvironment. These analytical methods provide details about the architecture and nature of these supramolecular carbene precursors.