Iodipamide (Cholografin) Administration

Abstract

AFTER the administration of iodine-containing x-ray contrast mediums, such as iodoalphionic acid (Priodax), iodopyracet (Diodrast) and iodinated oil (Lipiodol), a decrease in the thyroid uptake of radio-active iodine (I131) and an increase in the serum precipitable iodine occur. These effects are considered to be a result of the liberation of iodide from these organic molecules.1 In a recently developed x-ray contrast medium, iodipamide (Cholografin, disodium N, N'-adipyl-bis [3-amino-2,4,6,-triiodo] benzoic acid),§ the iodine content was found to remain firmly bound in the molecule after its intravenous injection.2 This observation suggested that this medium might not alter the thyroid uptake of . . .