Chemical Communications · 2011 · 35 citations · 29 references
Life SciencesBiotechnologyMolecular BiologyBiosensorsMolecular BiotechnologyMolecular RecognitionDna BiosensorsMolecular Probe DevelopmentMolecular SensorsNucleic Acid LabelingDna ProbesFluorescent Nucleic Acid ProbesFluorescent ProbesMolecular Beacon AmplificationMolecular BeaconsSignal-to-background EnhancementSignal-to-background Ratio
In the presence of poly(L-lysine)-graft-dextran, an in-stem molecular beacon involving three perylene-anthraquinone pairs in the stem region had a signal/background ratio of as high as 570. Response speed was also remarkable; equilibrium was attained within 5 minutes after addition of substrate DNA at 20 °C.
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Wavelength-shifting molecular beacons
Sanjay Tyagi, Salvatore A. E. Marras, Fred Russell Kramer · Nature Biotechnology · 2000 · 337 citations