Strategy for ¹⁴C‐labeling of a series of bis(heteroaryl)piperazines

Abstract

Abstract Four bis(heteroaryl)piperazines labeled with carbon‐14 in the 2‐position of imidazole moiety were prepared as part of a 4‐step (or 5‐step) sequence from 5‐hydroxymethyl‐2‐mercapto‐1‐benzylimida‐zole‐[2‐ 14 C] as a key synthetic intermediate which has been synthesized from potassium [ 14 C]‐thiocyanate. Copyright © 2011 John Wiley & Sons, Ltd.