SYNTHESIS AND REACTIONS OF SOME NEW 5-CARBONYL(4-AMINO-3-CYANO-2-SUBSTITUTED THIOPHENE-5-YL)-8-HYDROXYQUINOLINE (PART II). SYNTHESIS OF THIAZOLE; ISOXAZOLE; PYRAZOLE, PYRIMIDINE AND PYRIDAZINE DERIVATIVES AS POSSIBLE ANTIMICROBIAL AGENTS

Abstract

Abstract 5-Carbonyl-(3,4-diamino-2-ethylcarboxylatethieno[2,3-b]thiophene-5yl)-8-hydroxyquino-line (1) reacts with various reagents to afford thiazole, oxadiazole, pyrazole, isoxazole, pyrimidine and pyridazine derivatives (2–13d). The structure of the compounds has been established by elemental analysis. IR, NMR and mass spectra. The compounds thus synthesized were screened for their antimicrobial activity.