Regulation of Reduced-Folate Transporter-1 in Retinal Pigment Epithelial Cells by Folate

Abstract

Excess folate levels downregulate RFT-1 in RPE. This study represents the first molecular analysis of the regulation of RFT-1 by folate in RPE and reveals attenuation of the activity and expression of a folate transport protein under conditions of high levels of folate.