Prolonged Decrease of Adipocyte Size after Rosiglitazone Treatment in High‐ and Low‐Fat‐Fed Rats

Abstract

These results demonstrated that TZD-induced effects on adipocyte size and number were maintained after discontinuing treatment, even with consumption of an obesigenic diet. However, additional studies are needed to determine whether TZD-treated animals eventually achieve an adipocyte size similar to that of untreated animals at the expense of a higher BW.