Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

Valeria Petronilli, Paola Costantini, Luca Scorrano et al. · Journal of Biological Chemistry · 1994 · 532 citations · Full text

Life Sciences, Biochemistry, Biophysics +17

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.

Paolo Bernardi, Stefano Vassanelli, Paola Veronese et al. · Journal of Biological Chemistry · 1992 · 452 citations · Full text

Life Sciences, Biophysics, Cell Biology +9

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

Ildikò Szabó, Mario Zoratti · Journal of Biological Chemistry · 1991 · 369 citations · Full text

Life Sciences, Biophysics, Pharmacology +17

Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria

M Crompton, A Costi, L. Hayat · Biochemical Journal · 1987 · 333 citations · Full text

Life Sciences, Biochemistry, Biophysics +16

Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria.

Valeria Petronilli, Carmen Cola, Stefano Massari et al. · Journal of Biological Chemistry · 1993 · 318 citations · Full text

Life Sciences, Biophysics, Physiology +17